Clinical effect of olmesartan on hemorrheology in essential hypertensive patients
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摘要: 目的 观察奥美沙坦酯对原发性高血压患者血流动力学的影响.方法 32例原发性高血压患者(奥美沙坦组)服用奥美沙坦20～40 mg/d10个月,另选30例原发性高血压患者服用复方降压片作为对照组,观察治疗前、后血流动力学指标的变化.结果 奥美沙坦组服用奥美沙坦10个月后血压明显下降(P＜0.01),全血低切黏度(ηb)、血浆黏度(ηp)及红细胞聚集指数(AI)全血低切还原黏度 红细胞电泳 纤维蛋白原(Fib)均显著降低(P＜0.01)；全血高切黏度、全血高切还原黏度、红细胞比容和红细胞刚性指数(RRI)也有所下降,但无统计学意义(P＞0.05).对照组治疗后仅ηb、ηp及AI较治疗前显著降低.结论 原发性高血压患者服用奥美沙坦酯后在血压显著降低的同时,其红细胞聚集性 Fib下降和红细胞变形能力增强,红细胞比容、血黏度降低.
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