Objective To explore the effect of Yiqi Tongluo Anshen Recipe combined with statins on coronary blood flow and blood pressure in patients with coronary heart disease complicated with hypertension.
Methods A total of 120 patients with coronary heart disease combined with hypertension were selected as study objects, and were divided into two groups according to treatment methods, with 60 patients in each group. The conventional group was treated with amlodipine tablets combined with atorvastatin calcium tablets, and the Anshen prescription group was treated with Yiqi Tongluo Anshen Recipe on the basis of the conventional group. The levels of Salusin-β, lipoprotein-associated phospholipase A2 (LP-PLA2), high-sensitivity C-reactive protein (hs-CRP), pentamylin 3 (PTX3), tumor necrosis factor-α (TNF-α) and blood pressure of the two groups were recorded before and after treatment, and the TIMI3 rate of coronary blood flow in myocardial infarction thrombolysis test (TIMI) and the adverse reaction rate during treatment were analyzed.
Results The total effective rate of TCM syndrome in the Anshen prescription group was higher than that in conventional group (P < 0.05). After treatment, systolic blood pressure (SBP) and diastolic blood pressure (DBP) in two groups were lower than before treatment, and SBP and DBP in the Anshen prescription group were lower than those in the conventional group (P < 0.05). The rate of coronary blood flow TIMI3 in the Anshen prescription group was higher than that in the conventional group (P < 0.05). After treatment, levels of Salusin-β, LP-PLA2, PTX3, hs-CRP and TNF-α in two groups were decreased compared with those before treatment, and levels of Salusin-β, LP-PLA2, PTX3, hs-CRP and TNF-α levels of in the Anshen prescription group after treatment were lower than those in the conventional group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the Anshen prescription group and the conventional group (P>0.05).
Conclusion Yiqi Tongluo Anshen Recipe combined with statins in the treatment of coronary heart disease with hypertension can reduce the expression of related factors, improve coronary blood flow and the curative effect.
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