Objective To investigate the clinicopathological and ultrasonic characteristics of different molecular types of breast cancer with maximum diameter ≤2 cm, and analyze the diagnostic value of conventional ultrasound.
Methods A total of 174 breast cancer patients with diameter ≤2 cm were selected as the study objects. According to the immunohistochemical results, they were divided into LA group (Luminal A, n=46), LB group (Luminal B, n=71), HER-2 group (HER-2 overexpression type, n=11) and triple-negative group (triple-negative, n=46). The clinicopathology, ultrasonic characteristics and the accuracy of conventional ultrasonic diagnosis were analyzed.
Results There were significant differences in breast cancer size, pathological grade and pathological type among four groups (P < 0.05). Among the ultrasonic characteristics, there were statistically significant differences in shape, edge, aspect ratio, calcification and rear echo among the four groups (P < 0.05). Breast Imaging Reporting and Data System (BI-RADS) grading and accuracy of conventional ultrasound diagnosis among the four groups showed statistically significant differences (P < 0.05).
Conclusion The clinicopathological features, ultrasound features and BI-RADS grading of different molecular types of breast cancer with maximum diameter ≤2 cm are different. Routine ultrasound has certain diagnostic value, which can provide important reference for molecular classification diagnosis, individualized treatment and prognosis evaluation of early breast cancer.
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