Changes and influencing factors of changes of atrial electromechanical delay time in non-dialysis patients with stage 3 to 5 chronic kidney disease

Objective To evaluate the atrial electromechanical delay (AEMD) time in non-dialysis patients with chronic kidney disease (CKD) in stage 3 to 5 by tissue Doppler imaging (TDI) and its influencing factors.

Methods Sixty healthy subjects were selected as control group, and 104 non-dialysis patients in stage 3 to 5 CKD were selected as case group, all of whom underwent echocardiography. The correlations of AEMD time with other parameters and indicators were evaluated by Pearson's correlation coefficient.

Results Compared with the control group, the electromechanical coupling time(PA) lateral, septal PA, PA tricuspid valve the left atrial electromechanical delay time (EMD) and interatrial EMD time in the case group were significantly prolonged (P < 0.05). The PA interval was positively correlated with triglyceride (P < 0.05); the left atrial EMD time and interatrial EMD time were positively correlated with systolic blood pressure, diastolic ventricular septal thickness(IVSd), left ventricular end-diastolic diameter(LVEDd), left ventricular end-systolic diameter(LVESd), left ventricular end-diastolic posterior wall thickness (LVPWTd) as well as the early mitral ring diastolic flow rate/early myocardial diastolic velocity(E/e'), and negatively correlated with estimated glomerular filtration rate(eGFR)(P < 0.05).

Conclusion The PA lateral, PA interval, left atrium EMD time and interatrial EMD time are significantly prolonged in patients. The SBP, triglyceride, myocardium structure, E/e' and eGFR may be the influencing factors for the prolonged AEMD time in these patients.