Objective To observe the application effect of Wenshen Formula in treating patients with spleen and kidney yang deficiency syndrome after operation of Hashimoto's thyroiditis complicated with differentiated thyroid carcinoma (DTC).
Methods Ninety-eight patients with Hashimoto's thyroiditis combined with spleen-kidney Yang deficiency syndrome after DTC surgery admitted to the hospital from November 2019 to February 2022 were included in this study, and were divided into observation group (n=49) and control group (n=49) according to random number table method. Both groups were treated with thyroid stimulating hormone (TSH) inhibition therapy, and the control group was treated with Jinshuibao Capsule on this basis. Combined with the principle of warming kidney, strengthening spleen and removing dampness. in treatment of spleen and kidney yang deficiency syndrome by Professor Chen Ruquan, a famous TCM doctor, the patients in the observation group were treated with self-made Wenshen Formula. The clinical efficacy, TCM symptom score, thyroid hormone indexesserum free triiodothyronine (FT3), serum free thyroxine (FT4), TSHlevels of the two groups were observed after treatment, and the occurrence of adverse reactions of the two groups during treatment were recorded.
Results After treatment, the total effective rate of the observation group was significantly higher than that of the control group (P < 0.05). The observation group had lower scores of aversion to chills of four limbs, fatigue, dizziness, blurred vision, dry mouth and throat, lack of breath and laziness to speak, chest tightness and shortness of breath than the control group (P < 0.05). Compared with control group, the level of TSH in the observation group was lower, and the levels of serum FT3 and FT4 were higher (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P>0.05).
Conclusion Wenshen Formula has a good therapeutic effect in patients with Hashimoto's thyroiditis complicated with DTC differentiated as spleen and kidney Yang deficiency syndrome after surgery, can significantly improve the clinical symptoms, regulate the thyroid hormone level, improve thyroid function, and has no increase in the incidence of adverse reactions.
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