Objective To investigate the correlation between HLA-B*1502 gene and cutaneous adverse drug reactions (cADRs) after treatment of aromatic antiepileptic drugs (AEDs) in children with epilepsy in Hainan area.
Methods A total of 100 children with epilepsy in our hospital from January 2020 to July 2022 were enrolled and treated with aromatic AEDs, and they were divided into cADRs group (n=32) and non-CADRs group (n=68) according to the occurrence of cADRs. HLA-B*1502 gene test was performed for the children, and HLA-B*1502 genotype and allele frequency were recorded. According to the severity of cADRs, the children with mild reactions were included in mild group, and the children with Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug hypersensitivity syndrome (DHS) were included in severe group. HLA-B*1502 genotypes in the children with different severity levels were compared; the correlation between HLA-B*1502 gene and cADRs was analyzed.
Results he proportion of CT type in HLA-B*1502TB locus in the cADRs group was significantly higher than that in the non-cADRs group (68.75% versus 36.76%), while theproportion of CC type was significantly lower than that in the non-cADRs group (28.13% versus 63.24%) (P < 0.05). T allele frequency of HLA-B*1502TB locus in the cADRs group was 37.50%, which was significantly higher than 18.38% in the non-cADRs group (P < 0.05). There were no significant differences in genotype and allele frequency of HLA-B*1502 gene between the mild group and the severe group (P>0.05). Logistic regression analysis showed that CT genotype and T allele of HLA-B*1502TB locus can increase the occurrence risk of cADRs after AEDs treatment in children with epilepsy in Hainan area (P < 0.05).
Conclusion After treatment of aromatic AEDs, the occurrence of cADRs in children with epilepsy in Hainan area is closely related to the HLA-B*1502 gene. Children with CT genotype and T allele at HLA-B*1502TB locus have a higher occurrence risk of cADRs.
DownLoad: