Analysis of high-risk factors of severe cardiovascular sequelae in Kawasaki disease

Objective To analyze the high-risk factors of severe cardiovascular sequelae (SCS) in children with Kawasaki disease (KD).

Methods A total of 505 KD patients were selected and divided into non-severe cardiovascular sequelae (N-GS) group (474 cases) and SCS group (31 cases) according to the presence of coronary artery disease (CAL). Age, gender, peripheral blood white blood cell count (WBC), fever duration, hemoglobin (Hb), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), plasma D-dimer assay (DD), antistreptomolysin O assay (ASO), Epstein-Barr virus (EBV), intravenous immunoglobulin (IVIG) nonresponse and recurrence of KD were correlated with KD complicated with SCS. The high-risk factors of KD concurrent SCS were analyzed.

Results Single factor analysis showed that ESR, PCT, fever time >10 days, KD recurrence and IVIG nonresponse were related to KD complicated with SCS (P < 0.05). Logistic regression analysis showed that fever time >10 days (OR=6.73; 95%CI, 1.75 to 22.94; P=0.02), KD recurrence (OR=3.87; 95%CI, 1.43 to 8.55; P=0.04) and IVIG nonresponse (OR=4.28; 95%CI, 1.62 to 9.75; P=0.03) were independent high-risk factors for KD complicated with SCS.

Conclusion Fever time >10 days, KD recurrence and IVIG nonresponse are high-risk factors for KD complicated with SCS.