Objective To investigate the relationships of inflammatory factors levels with insulin resistance and glycolipid metabolism indicators in patients with type 2 diabetes mellitus (T2DM) and its value in predicting microangiopathy.
Methods A total of 1 008 patients with T2DM were selected as the research objects, of which 405 patients with microangiopathy were assigned to microangiopathy group, and 603 patients without microangiopathy were assigned to non-microangiopathy group. The levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of β cell function (HOMA-β), fasting blood glucose (FBG), 24-hour mean blood glucose (MBG), 24-hour blood glucose fluctuation (BGFR), 24-hour standard deviation of blood glucose (SDBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were compared between the two groups. The correlations of IL-6, IL-1β, CRP and TNF-α with HOMA-IR, HOMA-β, FBG, MBG, BGFR, SDBG, TC, TG, HDL and LDL levels were analyzed. The predictive efficacy of combined detection of IL-6, IL-1β, CRP and TNF-α for microangiopathy was analyzed.
Results The levels of IL-6, IL-1β, CRP, TNF-α, HOMA-IR, HOMA-β, FBG, HbA1c, MBG, BGFR, SDBG, TG, TC and LDL in the microangiopathy group were significantly higher than those in the non-microangiopathy group, while HDL was significantly lower than that in the non-microangiopathy group (P < 0.05). Correlation analysis showed that IL-6, IL-1β, CRP and TNF-α were positively significantly correlated with HOMA-IR, HOMA-β, FBG, MBG, BGFR, SDBG, TC, TG and LDL (P < 0.001), and were negatively significantly correlated with HDL (P < 0.001). The receiver operating characteristic (ROC) curve analysis showed that the thresholds of IL-6, IL-1β, CRP and TNF-α for the occurrence of microangiopathy in patients with T2DM were 34.42 pg/mL, 1.53 pg/mL, 6.84 mg/mL and 44.11 pg/mL, respectively.
Conclusion In patients with T2DM, level of inflammatory factors is correlated with glycolipid metabolism and insulin resistance, and combined detection of multiple inflammatory factors shows a significant predictive value for microangiopathy.
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