Clinical application of platelet-rich plasma therapy combined with autologous skin grafting to repair small area bone exposed wound

Objective  To observe the clinical effect of platelet-rich plasma(PRP)therapy combined with simultaneous autologous skin grafting in repairing small area bone exposed wound after trauma.

Methods  A total of 60 cases of bone exposed wounds were selected as study objects, and were divided into control group (artificial dermis combined with skin graft) and observation group (PRP combined with skin graft) according to different surgical methods, with 30 cases in each group. The survival rate of skin graft, the length of hospital stay and operation cost were observed and compared at 10 days after skin grafting. Visual Analog Scale (VAS) score was evaluated at 1 day and 5 days after surgery to assess the pain degree. Vancouver Scar Scale (VSS) scores were evaluated at 6 months postoperative follow-up.

Results  Compared with the control group, the hospitalization time in the observation group shorter, and the operation cost was lower (P < 0.05). VAS score at 1 day after surgery in the observation group was lower than that in the control group (P < 0.05). However, there was no significant difference in VAS score 5 days after surgery and skin survival rate 10 days after surgery between the observation group and the control group (P>0.05). Six months after surgery, the VSS score of the observation group was lower than that of the control group (P < 0.05).

Conclusion  PRP therapy combined with simultaneous autologous skin grafting is effective in repairing small area bone exposure wounds, and can relieve postoperative pain and scar formation, shorten hospital stay and reduce surgical costs.