Objective To explore the values of platelet aggregation rate (PAG), platelet membrane glycoprotein (GP) and other laboratory indicators in predicting risk of major adverse cardiovascular events (MACE) in elderly patients after percutaneous coronary intervention (PCI).
Methods A total of 108 coronary heart disease patients with PCI were selected, the incidence of MACE within 6 months after PCI was evaluated and recorded, and the patients were divided into MACE group (n=17) and no MACE group (n=91). PAG, GPⅡb/Ⅲa fibrinogen receptor (PAC-1), P-selectin (CD62P) and other related laboratory indexesplatelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), prothrombin time (PT), serum creatinine (Scr), and total cholesterol (TC)were compared between the two groups; the receiver operating characteristic (ROC) curve was used to analyze the values of PAG, PAC-1, CD62P, PT and Scr in predicting MACE, and the multivariate Logistic regression analysis was used to analyze the risk factors of MACE.
Results The ratios of patients with age>70 years old and diseased vessels ≥ 3 in the MACE group were significantly higher than those in the no MACE group, the levels of PAG, PAC-1, CD62P and Scr were significantly higher than those in the no MACE group, and the levels of left ventricular ejection fraction (EF) and PT were significantly lower than those in the no MACE group (P < 0.05). ROC curve analysis showed that the areas under the curve of PAG, PAC-1, CD62P, PT and Scr in predicting MACE were 0.895, 0.894, 0.806, 0.937 and 0.672 respectively. Multivariate Logistic regression analysis showed that age>70 years old, diseased vessels ≥ 3, EF < 53%, PAG>43.155%, PAC-1>15.560%, CD62P>15.100%, PT < 14.975 s and Scr>83.810 μmol/L were the risk factors of MACE (P < 0.05).
Conclusion High levels of PAG, GP, PAC-1, CD62P and Scr as well as low levels of PT and EF are risk factors for MACE in patients with coronary heart disease after PCI.
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