Effect of Jieyu Huatan Xiaoyu Decoction in treatment of precancerous lesions of gastric cancer with syndrome of disharmony between liver and stomach

Objective To observe the effect of Jieyu Huatan Xiaoyu Decoction in precancerous lesions of gastric cancer patients with syndrome of disharmony between live and stomach, and to explore the advantages and characteristics.

Methods A total of 80 patients were randomly divided into treatment group(n=40) and control group(n=40). Patients in the treatment group were treated with Jieyu Huatan Xiaoyu Decoction and those in the control group were treated with Moluodan. Treatment of both groups was lasted for 6 months. The syndrome scores of traditional Chinese medicine(TCM), gastroscopic mucosal pathology scores, Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scores were compared between the two groups before and after treatment, and the efficacy of the two groups was comprehensively compared.

Results After 6 months of treatment, the syndrome scores of epigastric or hypochondriac distension, belching and acid regurgitation, chest tightness, diet reduction, and constipation score decreased in the two groups, and the above syndrome scores and total score in the treatment group were better than those in the control group(P < 0.05). After 6 months of treatment, the scores of endoscopic gastric mucosa atrophy, intestinal metaplasia and dysplasia in the two groups were lower than those before treatment, and the scores of gastric mucosa atrophy and intestinal metaplasia in the treatment group were lower than those inthe control group (P < 0.05). After 6 months of treatment, the scores of HAMA and HAMD of patients in the treatment group scored (9.33±2.08) and (8.38±2.13), which were lower than (17.58±3.36) and (13.33±3.40) respectively before treatment. The HAMA score ofthe control group was (14.43±2.71) after 6 months of treatment, which was lower than (17.03±4.05) before treatment (P < 0.05). After 6 months of treatment, HAMA and HAMD scores of the treatment group were lower than those of the control group (P < 0.05). The total effective rate of the treatment group was 95.00%(38/40), which was higher than 77.50% (31/40) in the control group (P < 0.05).

Conclusion Jieyu Huatan Xiaoyu Decoction can effectively improve the pathological changes of gastric mucosa and the state of anxiety and depression in patients with precancerous lesions of gastric cancer with syndrome of disharmony between liver and stomach.