Objective To compare the effects of magnesium sulfate and nifedipine on hemodynamics and pregnancy outcomes of pregnant women with hypertensive disorders complicating pregnancy (HDCP).
Methods A total of 114 pregnant women with HDCP were selected as research objects, and were divided into observation group (treated by nifedipine) and control group (treated by magnesium sulfate) according to random number table method, with 57 cases in each group. The levels of whole blood high shear viscosity (HBV), whole blood low shear viscosity (LBV), plasma viscosity (PV), anti-cardiolipin antibody immunoglobulin G (ACA-IgG) and anti-cardiolipin antibody immunoglobulin M (ACA-IgM) in pregnant women in two groups were detected, and their adverse reactions and pregnancy outcomes were observed.
Results Before treatment, there were no significant differences in HBV, LBV, PV, ACA-IgG, ACA-IgM between the two groups (P>0.05). After treatment, the levels of HBV, LBV, PV, ACA-IgG and ACA-IgM in two groups were lower than treatment before, and were lower in the observation group than those in the control group (P < 0.05). The total incidence of adverse reactions in the observation group was 7.02%, which showed no statistically significant difference compared with 5.26% in the control group (P>0.05). The premature birth rate, neonatal asphyxia rate and cesarean section rate in the observation group were 10.53%, 3.51% and 22.81%, which were lower than 31.58%, 21.05% and 43.86% in the control group (P < 0.05).
Conclusion Both magnesium sulfate and nifedipine in treating HDCP can improve hemodynamics and pregnancy outcomes, but nifedipine has better improvement in efficacy.
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