Effects of refined black sesame oil on amiodarone-induced phlebitis

Objective To investigate effects of refined black sesame oil (sesame oil) on amiodarone-induced phlebitis.

Methods A total of 50 hospitalized patients who received intravenous infusion of amiodarone hydrochloride in department of cardiovascular medicine were randomly divided into experimental group and control group, with 25 cases in each group. One case was lost during follow-up in the control group. Patients in the experimental group were fixed with 3M transparent dressing without tension and five drops of sesame oil were applied to the skin within a 10 cm radius of the infusion site prior to the administration of amiodarone until they were completely absorbed. Sesame oil was used every 6 h and for 4 times in total. The indwelling needle was fixed with hydrocolloid dressing after puncture in the control group. The incidence of phlebitis of two groups was compared, and severity of phlebitis and occurrence time of phlebitis was recorded.

Results No significant differences were found in the incidence rates of phlebitis between the two groups at different time points (P>0.05). The total incidence of phlebitis in the experimental group was lower than that in the control group (48.00% versus 83.33%, P < 0.05), and the severity of phlebitis was lower than that in the control group, and the occurrence time of phlebitis was latter than that in the control group(P < 0.05).

Conclusion The application of sesame oil on the puncture sites can reduce the incidence of phlebitis caused by amiodarone hydrochloride injection, relieve the severity of phlebitis, and delay the occurrence of phlebitis.