Objective To analyze the effect of drug therapy combined with stent implantation on cerebral perfusion, cognitive function and short-term prognosis in patients with symptomatic intracranial atherosclerotic stenosis (SICAS).
Methods A total of 124 hospitalized patients with SICAS were collected and divided into therapy-alone treatment group (60 cases, medicinal therapy only) and combination group (64 cases, medicinal therapy combined with stenting) according to the therapeutic methods.Regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), and mean transit time (MTr) were analyzed by CT cerebral perfusion imaging before and 10 d after treatment.Montreal Cognitive Assessment Scale (MoCA) score and National Institutes of Health Stroke Scale (NIHSS) score were compared between two groups 3 and 14 days after treatment.The complication rate was compared between two groups after 12-month follow-up.
Results Compared with before treatment, rCBF and rCBV of the combination group were increased, while MTr was decreased after treatment (P < 0.05).After treatment, there were significant differences in CBF, rCBV and MTr between two groups (P < 0.05).After treatment, the MoCA scores of the two groups were increased, and MoCA scores 3 and 14 days after treatment showed significant differences between the two groups (P < 0.05). The NIHSS scores 3 and 14 days after treatment of two groups were significantly decreased, and the NIHSS score of the combination group was significantly lower than the therapy-alone treatment group (P < 0.05).The incidence rate of complications of the combination group was significantly lower than that of the therapy-alone treatment group (P < 0.05).
Conclusion Stenting combined with medicinal therapy can improve the cerebral perfusion volume and cognitive function for SICAS, improve the nerve function, and decrease the incidence of complication.
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