Relations between clinical parameters and depression as well as cognitive function among dialysis patients

  Objective  To explore the relations between clinical parameters and depression as well as cognitive function among dialysis patients.

  Methods  The clinical data of 186 dialysis patients(including hemodialysis and peritoneal dialysis) was retrospectively analyzed. The depression and cognitive function of patients were scored using Hamilton Depression Scale-24 (HAMD-24) and Clinical Dementia Rating Scale (CDR), respectively. Pearson bivariate correlation analysis was used to explore the correlation between basic clinical indicators and depression level, cognitive function. Multiple linear regression analysis was used to investigate the independent risk factors of depression and cognitive dysfunction in dialysis patients.

  Results  Of the 186 dialysis patients, 75 people (40.32%) had moderate or severe depression. There were significant differences in age, blood pressure, albumin and β₂ microglobulin levels between hemodialysis and peritoneal dialysis patients(P < 0.05). Diastolic blood pressure, hemoglobin, phosphorus, albumin, β₂ microglobulin, CDR scores were correlated with depression. Age, diastolic blood pressure and phosphorus levels were associated with cognitive impairment. High phosphorus was an independent risk factor for both depression and cognitive dysfunction.

  Conclusion  Dialysis patients with end-stage renal disease are prone to present depression and cognitive dysfunction. Increase of serum phosphorus level is the independent risk factor associated with both depression and cognitive dysfunction.