Effect of enhanced recovery after surgery on prognosis and inflammatory response of patients undergoing laparoscopic colorectal cancer surgery

  Objective  To compare the effects of enhanced recovery after surgery (ERAS) on prognosis and inflammatory response of patients undergoing laparoscopic colorectal cancer surgery.

  Methods  Eighty patients who underwent elective laparoscopic resection of colorectal cancer were selected as research subjects and randomly divided into control group (n=40) and study group (n=40). The control group was given perioperative management according to the traditional scheme, while the study group was given perioperative management based on ERAS. Serum levels of inflammatory cytokinesinterleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α)at time points of preoperation (T₁), postoperative 12 hours (T₂), postoperative 24 hours (T₃), and postoperative 48 hours (T₄) of two groups were compared. The amount of intraoperative blood loss, perioperative dose of opioids, indwelling time of abdominal drainage tube and postoperative exhaust defecation, length of hospital stay, Visual Analog Scale (VAS) score and incidence of complications were compared between the two groups.

  Results  Compared with T₁, the serum levels of inflammatory factors at time points of T₂ to T₄ were significantly higher (P < 0.05). At T₁, there was no significant difference in serum inflammatory cytokines between the two groups (P>0.05). The serum inflammatory factors of the study group at T₂, T₃ and T₄ were significantly lower than those in the control group (P < 0.05). Compared with the control group, the perioperative opioid dosage of the study group was significantly less, indwelling time of abdominal drainage tube and postoperative hospitalization time were shorter, and postoperative VAS score and complication rate were significantly lower than the control group than those of the control group (P < 0.05).

  Conclusion  ERAS for patients undergoing laparoscopic colorectal cancer surgery can effectively reduce the level of inflammatory factors, relieve pain, shorten the length of hospital stay and reduce the incidence of postoperative complications.