Effect of different anesthesia methods on hemodynamics and immune function for patients with lung cancer

Objective To explore the effect of different anesthesia methods for patients with lung cancer and its influences on stress indexes, hemodynamics and immune function. Methods A total of 100 patients with lung cancer were divided into control group(n=50)and observation group(n=50)according to different anesthesia methods. The control group was given general anesthesia, and the observation group was given ultrasound-guided paravertebral block. The anesthesia effect, perioperative changes of hemodynamics, stress indexes and immune function were compared between the two groups. Results Visual Analogue Scale(VAS)scores at 4 and 12 h after operation in the observation group were significantly lower than those in the control group(P<0.05). There was no statistically significant difference in postoperative Ramsay scores between the two groups(P>0.05). At 4 h after operation, heart rate(HR), systolic blood pressure(SBP)and mean arterial pressure(MAP)in the observation group were significantly lower than those in the control group(P<0.05). The levels of cortisol, tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the observation group were significantly lower than those in the control group(P<0.05). The levels of CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺ in the observation group were significantly higher than those in the control group(P<0.05). Conclusion Ultrasound-guided paravertebral block can improve the stress indexes, and has little impacts on the hemodynamics and immune function for lung cancer surgery patients.