Effect of oxygen resuscitation at a concentration of 40% on resuscitation, brain injury and oxygen poisoning in asphyxiated neonates

  Objective  To investigate the effect of oxygen resuscitation at a concentration of 40% on resuscitation, brain injury and oxygen poisoning in asphyxiated neonates.

  Methods  The clinical data of 80 asphyxiated newborns admitted to our hospital were retrospectively analyzed. They were divided into air resuscitation group (n=35) and 40% of oxygen concentration group (n=45) according to different oxygen concentrations, given the same other basic resuscitation treatments and nursing, and were transferred to neonatal care unit after resuscitation. The time to first crying, time to establishment of spontaneous breathing and the Apgar score at 1, 5 and 10 min after birth of asphyxiated newborns in the two groups were observed. The success rate of resuscitation, complications such as brain injury and oxygen poisoning were compared between the two groups.

  Results  The success rate of resuscitation was 100.00% in both groups, and there were no deaths. The time to first crying and the time to establishment of spontaneous breathing in 40% of oxygen concentration group were shorter than those in air resuscitation group (P < 0.05). There was no significant difference in Apgar score at 1 min after birth between the two groups (P>0.05). Apgar scores at 5 and 10 min after birth in 40% of oxygen concentration group were (7.72±1.23) and (6.68±1.37) points, respectively, which were significantly higher than (6.68±1.37) and (8.78±0.84) points, respectively, in air resuscitation group(P < 0.05). The Neonatal Behavioral Neurological Assessment (NBNA) score at 2 to 3 days after resuscitation in 40%of oxygen concentration group was higher, and the incidence of brain injury was lower than that of air resuscitation group (P < 0.05). There was no significant difference in the incidence of neonatal oxygen poisoning between the two groups (P>0.05).

  Conclusion  Oxygen resuscitation at a concentration of 40% and air oxygen concentration resuscitation both have satisfactory resuscitation success rate of asphyxiated neonates, but the former has more advantages in improving clinical symptoms of neonatal asphyxia and preventing brain injury, and does not increase complications of oxygen poisoning.