Objective To investigate the effect of mesalazine combined with saccharomyces boulardii powder in treatment of patients with ulcerative colitis (UC).
Methods Totally 80 UC patients were selected and randomly divided into two groups. The control group was treated with mesalazine, while the study group was treated with mesalazine combined with saccharomyces boulardii powder. The therapeutic effect, inflammatory factors before and after treatment, pathological changes of intestinal mucosa and recurrence rate were compared between the two groups.
Results The total effective rate of the study group was 97.50%, which was significantly higher than 77.50% of the control group (P < 0.05). After treatment, the levels of interleukin-17 (IL-17) and IL-6 in the studygroup were significantly lower than those in the control group (P < 0.05). The score of mucosal lesions in the study group was significantly lower than that in the control group (P < 0.05). The recurrence rate of the study group was significantly lower than that of the control group (P < 0.05).
Conclusion Mesalazine combined with saccharomyces boulardii powder is effective and safe in treatment of patients with UC.
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