Objective To explore the role of scutellaria baicalensis stem-leaf total flavonoid (SSTF) in regulating blood lipid level of rats with hypertriglyceride.
Methods Thirty-six SD rats were randomly divided into normal control group, model group, positive control group (fenofibrate) and low, medium and high doses of SSTF groups after one week of adaptive feeding. Except for the normal control group, the other five groups were fed with high-fat diet and given drug intervention at the same time. The positive control group was given fenofibrate 100 mg/kg, and the low, middle and high doses of SSTF groups were given 50, 100 and 200 mg/kg of SSTF respectively. Blood samples were collected from orbital venous plexus before administration and 6 weeks after drug intervention. Serum levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured.
Results After 6 weeks of feeding and drug intervention, the body weights of rats in low, medium and high doses of SSTF groups were significantly lower than that in model group (P < 0.05), but there were no significant differences when compared with normal control group and positive control group (P>0.05). The serum levels of TG, TC and LDL-C in low, middle and high doses of SSTF groups were significantly lower than those in model group (P < 0.05), and HDL-C was significantly higher than that in model group (P < 0.05), but there were no significant differences when compared with positive control group (P>0.05).
Conclusion Different doses of SSTF can effectively reduce the body weight increase of rats with hypertriglyceridemia, reduce the serum levels of TG, TC, LDL-C and increase the level of HDL-C, which indicate that SSTF has the effect of regulating blood lipid.
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