Application of subarachnoid anesthesia by bupivacaine combined with fentanyl in elderly patients with operation

  Objective  To investigate the application of subarachnoid anesthesia by bupivacaine combined with fentanyl in elderly patients with operation.

  Methods  A total of 156 elderly patients underwent surgery in our hospital were randomly divided into two groups, with 78 cases in each group. The control group was given bupivacaine for subarachnoid anesthesia, while the study group was treated with bupivacaine and fentanyl in combination for subarachnoid anesthesia. The anesthetic effects and changes of clinical indicators were compared between the two groups.

  Results  The complete time for anesthesia and anesthesia blocking time in the study group were significantly longer than those in the control group (P < 0.05), while the amount of local anesthesia was significantly less than that in the control group (P < 0.05). After the anesthesia, the levels of von Willebrand factor (vWF), fibrinogen (FIB), thrombin antithrombin complex (TAT), D-dimer in the study group were lower than those in the control group (P < 0.05); the systolic blood pressure, diastolic blood pressure and heart rate of the study group were higher than those of the control group after anesthesia (P < 0.05); the onset time of exercise block and its recovery time, onset time of analgesia, and pain recovery time in the study group were shorter than those in the control group (P < 0.05).

  Conclusion  Bupivacaine combined with fentanyl has significant effects on subarachnoid anesthesia in elderly patients.