Clinical, endocrine as well as metabolic characteristics and treatment of adolescent polycystic ovary syndrome

  Objective  To analyze the clinical, endocrine as well as metabolic characteristics and treatment of adolescent polycystic ovary syndrome (PCOS).

  Methods  A total of 105 adolescent PCOS patients were divided into routine group(n=49) and combined group(n=56). The clinical features and endocrine metabolic characteristics of the two groups were analyzed by collecting clinical data such as medical history, signs and Results of endocrine hormone test. The routine group was given estrogen therapy, while combined group was additionally given metformin for the treatment.

  Results  Adolescent PCOS patients were characterized by hirsutism, irregular menstruation, obesity and acne, who had disordered endocrine and metabolic mechanism, and increased levels of endocrine hormone such as follicular estrogen and serum luteinizing hormone. The total effective rate of the combined group was higher than that of the conventional group (P < 0.05). After treatment, the levels of follicle-forming hormone, serum luteinizing hormone and testosterone in the combined group were lower than that in the conventional group (P < 0.05). After treatment, the quality of life and anxiety scores in the combined group were better than those in the conventional group (P < 0.05), and the fasting and postprandial blood glucose in the combined group were lower than those in the conventional group (P < 0.05).

  Conclusion  Estrogen combined with metformin in treatment of adolescent PCOS patients can improve their symptoms and correct their endocrine and metabolic disorders.