Objective To explore the diagnostic value of serum transferrin (TRF), C reactive protein (CRP) and erythrocyte immune function detection in neonatal jaundice.
Methods A total of 100 jaundiced newborns from March 2016 to March 2018 and 80 full-term healthy newborns were collected in our hospital, and were divided into jaundice group and healthy group. Jaundice patients were further divided into physiological jaundice group (n=43), and pathological jaundice group (n=57) according to the type of jaundice and the level of total bilirubin (TBIL), mild to moderate jaundice group (n=69) and severe jaundice group (n=31) according to the severity degree of jaundice. The levels of TRF, CRP, erythrocyte immune complex resette(RBC-ICR), erythrocyte C3b receptor rosette(RBC-C3bR) and erythrocyte immune affinity receptor(FEER) in serum of the newborns were detected. The differences of the above indexes between jaundice group and its subgroups, healthy group were compared.
Results Compared with the healthy group, the levels of TRF, RBC-C3bR, FEER in jaundice group were significantly lower, while levels of CRP and RBC-ICR were significantly higher (P < 0.05). The levels of TRF, RBC-C3bR and FEER in serum of physiological jaundice group were higher than that in pathological jaundice group, while the levels of CRP and RBC-ICR were significantly lower than that in pathological jaundice group(P < 0.05). The levels of TRF, RBC-C3bR and FEER in mild and moderate jaundice group were significantly higher than that in severe jaundice group, while the levels of CRP, RBC-ICR in mild and moderate jaundice group were significantly lower than those in severe jaundice group (P < 0.05).
Conclusion The levels of serum TRF, CRP and erythrocyte immune function of jaundiced neonates show abnormal status, and there are significant differences between different types and different severity degrees of jaundiced neonates, which is of great value for clinical diagnosis of neonatal jaundice.
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