Efficacy observation and evaluation of cefepime in the treatment of bacterial infection of gynecology

Objective To evaluate the efficacy and safety of cefepime in the treatment of bacterial infection of gynecology.Methods 235 bacterial infection patients were randomly divided into test group (n =118)and control group (n =117).The clinical observation was done according to Guidelines for Clinical Research of Antibiotics issued by Ministry of Health of the People′s Repub-lic of China.The control group was treated with intravenous injection of ceftazidime for 2.0 g added into 250 mL of Sodium Chloride Injection (concentration of 0.9%)twice a day,while the test group was treated with cefepime 2.0 g added into 250 mL of Sodium Chloride Injection(concentra-tion of 0.9%)twice a day.The treatment periods for the two groups were both 7 to 14 days.The efficacy and safety were observed and compared.Results The clinical cure rates of the test group and the control group were 50.85% and 37.61% respectively;The effective rates were 92.37%and 79.49% respectively,and the clearance rates of bacteria were 90.83% and 75.47% respective-ly.There was significant difference between the two groups (P <0.01).No serious adverse reac-tion was found during the clinical research.Conclusion Cefepime is more safety,effective,and has better clinical efficacy than ceftazidime in the treatment of bacterial infection of gynecology.