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李江科, 陈少军, 牛卫洲. 直接经皮冠状动脉腔内成形术联合支架置入术对急性心肌梗死患者N末端脑钠肽前体及QT间期离散度的影响[J]. 实用临床医药杂志, 2022, 26(3): 13-16. DOI: 10.7619/jcmp.20212957
引用本文: 李江科, 陈少军, 牛卫洲. 直接经皮冠状动脉腔内成形术联合支架置入术对急性心肌梗死患者N末端脑钠肽前体及QT间期离散度的影响[J]. 实用临床医药杂志, 2022, 26(3): 13-16. DOI: 10.7619/jcmp.20212957
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LI Jiangke, CHEN Shaojun, NIU Weizhou. Effect of direct percutaneous transluminal coronary angioplasty combined with stent implantation on N-terminal pro-B type natriuretic peptide and QT dispersion in patients with acute myocardial infarction[J]. Journal of Clinical Medicine in Practice, 2022, 26(3): 13-16. DOI: 10.7619/jcmp.20212957
Citation: LI Jiangke, CHEN Shaojun, NIU Weizhou. Effect of direct percutaneous transluminal coronary angioplasty combined with stent implantation on N-terminal pro-B type natriuretic peptide and QT dispersion in patients with acute myocardial infarction[J]. Journal of Clinical Medicine in Practice, 2022, 26(3): 13-16. DOI: 10.7619/jcmp.20212957
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直接经皮冠状动脉腔内成形术联合支架置入术对急性心肌梗死患者N末端脑钠肽前体及QT间期离散度的影响

Effect of direct percutaneous transluminal coronary angioplasty combined with stent implantation on N-terminal pro-B type natriuretic peptide and QT dispersion in patients with acute myocardial infarction

    摘要
  • 摘要:
      目的  探讨直接经皮冠状动脉腔内成形术(PTCA)联合支架置入术对急性心肌梗死(AMI)患者N末端脑钠肽前体(NT-proBNP)及QT间期离散度(QTd)的影响。
      方法  将100例AMI患者采取分层抽样法分为观察组(直接PTCA联合支架置入术治疗)和对照组(重组人组织型纤溶酶原激活物治疗)，每组50例。比较2组NT-proBNP、QTd、1年内心绞痛发生率、再发心肌梗死率、病死率、左室舒张末期内径(LVEDd)、左室射血分数(LVEF)、左室收缩末期内径(LVESd)及并发症发生情况。
      结果  治疗后，观察组的NT-proBNP、QTd低于对照组，差异有统计学意义(P < 0.05)。观察组1年内心绞痛发生率、再发心肌梗死率低于对照组，差异有统计学意义(P < 0.05)。治疗后，观察组LVEDd、LVESd低于对照组, LVEF高于对照组，差异有统计学意义(P < 0.05)。观察组并发症总发生率为4.00%, 低于对照组的18.00%, 差异有统计学意义(P < 0.05)。
      结论  直接PTCA联合支架置入术治疗AMI患者效果显著，可降低NT-proBNP水平、QTd数值及并发症发生率。

     

    Abstract:
      Objective  To investigate the effect of direct percutaneous transluminal coronary angioplasty (PTCA) combined with stent implantation on N-terminal pro-B type natriuretic peptide (NT-proBNP) and QT dispersion (QTd) in patients with acute myocardial infarction (AMI).
      Methods  A total of 100 AMI patients were divided into observation group (treated by direct PTCA and stent implantation) and control group (treated by recombinant human tissue plasminogen activator) according to stratified sampling method, with 50 cases in each group. NT-proBNP, QTd, 1-year incidence of angina pectoris, recurrent myocardial infarction rate, mortality, left ventricular end diastolic diameter (LVEDd), left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESd) and incidence of complications were compared between the two groups.
      Results  After treatment, NT-proBNP and QTd in the observation group were significantly lower than those in the control group (P < 0.05). The 1-year incidence of angina pectoris and recurrent myocardial infarction rate in the observation group were significantly lower than those in the control group (P < 0.05). After treatment, LVEDd and LVESd in the observation group were significantly lower than those in the control group, while LVEF was significantly higher than that in the control group (P < 0.05). The total incidence of complications in the observation group was 4.00%, which was significantly lower than 18.00% in the control group (P < 0.05).
      Conclusion  Direct PTCA combined with stent implantation shows a significant effect in the treatment of patients with AMI, which can reduce the NT-proBNP, QTd and incidence of complications.

     

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