Objective  To observe the efficacy of Yougui Pill combined with modified Erchen Decoction in treating patients with polycystic ovary syndrome (PCOS), and its impact on serum angiopoietin-like protein (Angptl)-2, Angptl-4 and soluble fms-like tyrosine kinase receptor (sFlt)-1.

  Methods  A total of 92 PCOS patients were divided into observation group and control group according to the random numerical method, with 46 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with Yougui Pill combined with modified Erchen Decoction on the basis of the control group. The efficacy and incidence of adverse reactions were compared between the two groups and the acne score, cervical mucus score, ovarian volume, follicle number, estradiol, luteinizing hormone, follicle stimulating hormone, prolactin, resistance index (RI), pulsatility index (PI), mean blood flow velocity (Vm), Angptl-2, Angptl-4 and sFlt-1 levels were compared in two groups before and after treatment.

  Results  The total effective rate in observation group was 95.65%, which was significantly higher than 78.26% in control group (P < 0.05). The incidence of adverse reactions in the observation group was 4.35%, which was significantly lower than 19.57% in the control group (P < 0.05). After treatment, the acne score, RI, PI, Vm, estradiol, luteinizing hormone, follicle stimulating hormone, prolactin, Angptl-2 and sFlt-1 levels of two groups were lower than treatment before, and were lower in the observation group than those in the control group(P < 0.01). After treatment, the ovarian volume in the two groups was smaller, and the number of follicles was less than that before treatment(P < 0.01). The ovarian volume was smaller and the number of follicles in the observation group was less than those in the control(P < 0.01). After treatment, the cervical mucus score and the level of Angptl-4 in the two groups were higher than before treatment, and the observation group was significantly higher than the control group (P < 0.01).

  Conclusion  Yougui Pill combined with modified Erchen Decoction in the treatment of polycystic ovary syndrome is obvious, which can significantly improve symptoms, reduce hormone levels and improve uterine blood circulation. The action mechanism may be related to the reduction of serum Angptl-2, Angptl-4 and sFlt-1 levels.