Abstract: Objective To observe the clinical manifestations of early pain after recovery in patients with general anesthesia and effect of targeted nursing. Methods Totally 76 patients with general anesthesia were randomly divided into observation group and control group, with 38 cases in each group. The anesthesia method was the same in both groups, the control group was treated with routine nursing, while the observation group was treated with targeted nursing. The heart rate(HR), mean arterial pressure(MAP), the scores of Ricker Sedation-Agitation Scale(SAS)and Visual Analogue Scale(VAS)were compared between the two groups before and after the intervention, and the nursing satisfaction degree and the incidence of nursing risk events were compared between the two groups. Results After the intervention, the HR, MAP, and scores of SAS and VAS in the observation group were significantly lower than those in the control group(P<0.05). The nursing satisfaction degree of the observation group was significantly higher than that of the control group, and the incidence of nursing risk events was significantly lower than that of the control group(P<0.05). Conclusion The pain is obvious in early awakening period in patients with general anesthesia, and they are usually accompanied by rapid HR, high MAP and other clinical manifestations. The implementation of targeted nursing can reduce the degree of pain in patients with general anesthesia in the early stage after recovery, and reduce the incidence of risk events such as agitation, tube removal and falling down from bed.