Abstract: Objective To explore the effect of atorvastatin on vascular endothelial function and blood lipid indexes in coronary heart disease patients with percutaneous coronary intervention(PCI). Methods A total of 90 patients with coronary heart disease after PCI were randomly divided into treatment group and control group, with 45 cases in each group. The control group was treated with conventional drugs for coronary heart disease, and the treatment group was treated with atorvastatin on the basis of the control group. Blood lipid indexes(including high-density lipoprotein, low-density lipoprotein, total cholesterol, triglyceride), vascular endothelial function indexes(vascular endothelial growth factor, nitric oxide)and incidence of adverse cardiovascular events were compared between the two groups before and after treatment. Results The levels of total cholesterol, triglyceride and low density lipoprotein in the treatment group were significantly lower than those in the control group(P<0.05), and the level of high-density lipoprotein was significantly higher than that of the control group(P<0.05). After treatment, the levels of vascular endothelial growth factor and nitric oxide in the treatment group were significantly higher than those in the control group(P<0.05). After treatment, the incidence of adverse cardiovascular events in the treatment group was 6.67%, which was significantly lower than 26.67% in the control group(P<0.05). Conclusion Atorvastatin is safe and effective in the treatment of patients with coronary heart disease after PCI, which can regulate levels of blood lipid indexes and reduce the incidence of adverse cardiovascular events.