Abstract: Objective To analyze the curative effect of rivaroxaban for patients with pulmonary embolism. Methods The clinical data of 80 patients with pulmonary embolism admitted in our hospital was retrospectively analyzed, and these patients were divided into two groups according to different treatment schemes. Forty patients treated with rivaroxaban were selected as rivaroxaban group, and another 40 patients treated with warfarin were selected as warfarin group. The arterial oxygen partial pressure［p(O₂)］ and incidence of bleeding were compared between the two groups. Results The total effective rates of the rivaroxaban group and warfarin group were 92.50%and 87.50%, respectively, and no significant difference was found(P>0.05). The p(O₂)increased and partial pressure of carbon dioxide［p(CO₂)］ decreased after treatment in both groups compared with before treatment(P<0.05). The incidence of bleeding in the rivaroxaban group was 7.50%, which was significantly lower than 30.00%in the warfarin group(P<0.05). Conclusion Rivaroxaban has significant effect on pulmonary embolism. It can improve arterial blood oxygen partial pressure, and has higher safety and no occurrence of bleeding.