Abstract: Objective To analyze the effects of Rosuvastatin Calcium Tablets on blood lipid indexes, cardiac function and inflammatory factor levels in patients with coronary heart disease and heart failure. Methods A total of 75 patients with coronary heart disease and heart failure included in the study were selected as research objects, and were divided into control and experimental groups, given normal dose of Rosuvastatin Calcium Tablets and high-dose of Rosuvastatin Calcium Tablets based on the conventional treatment, respectively. The clinical treatment effect, blood lipid indexes, cardiac function, inflammatory factor levels, and occurrence of adverse reactions of two groups were compared before and after treatment. Results The excellent rate of treatment in the experimental group was significantly higher than that in the control group(97.30% vs. 78.95%, P<0.05). Before treatment, there were no significant differences between the two groups in high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), triacylglycerol(TG), and total cholesterol(TC)(P>0.05). After treatment, LDL-C in the experimental group was significantly higher than that in the control group, and HDL-C, TG, and TC were significantly lower than those in the control group(P<0.05). Before treatment, there were no significant differences in left ventricular systolic diameter(LVESD), left ventricular ejection fraction(LVEF), and left ventricular end diastolic diameter(LVEDD)between the two groups(P>0.05). After treatment, LVEF in - the experimental group was higher, and LVESD as well as LVEDD were significantly lower than the control group(P<0.05). Before treatment, the levels of brain natriuretic peptide(BNP), tumor necrosis factor-α(TNF-α), and high sensitivity C reactive protein(hs-CRP)in the two groups showed no significant differences(P>0.05). After treatment, the levels of the above indicators in the experimental group were significantly lower than those in the control group(P<0.05). The total incidence of adverse reactions between the two groups showed no significant difference(P>0.05). Conclusion The application of Rosuvastatin Calcium Tablets in the treatment of coronary heart disease and heart failure can improve the blood lipid index of patients, strengthen their heart function, relieve inflammatory response, and has less adverse reactions.