Abstract: Objective To explore and study the effect of intelligent electronic nursing board on duty shifting process of nurses in neurosurgery department based on medical nursing information system. Methods From February to July 2019, the nurses who used traditional non-electronic nursing board were selected as control group, and those who used intelligent electronic nursing board from August 2019 to January 2020 were included in the observation group. The quality and time of shift before and after the installation of intelligent electronic nursing board were compared. Results After using the intelligent electronic nursing board, the shift quality score was significantly improved, and the time of shift was significantly shortened(P<0.05). Conclusion The application of intelligent electronic nursing board in duty shifting in neurosurgery department improves the timeliness and effectiveness of information interaction, enhances the quality of shift and reduces time of shift.