姜黄素治疗非酒精性脂肪性肝病的研究进展

Research progress of curcumin in the treatmentof non-alcoholic fatty liver disease

摘要: 非酒精性脂肪性肝病(NAFLD)是慢性肝损伤的原因之一，发病机制复杂。胰岛素抵抗、氧化应激、肠-肝轴和线粒体功能障碍等共同导致NAFLD的发生、发展。姜黄素是一种天然多酚类物质，是治疗NAFLD的潜在药物，并已广泛开展了实验研究。本研究对NAFLD的发病机制及姜黄素对NAFLD的治疗作用进行综述。

Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of causes of chronic liver injury, and the pathogenesis is complex. Insulin resistance, oxidative stress, intestinal-hepatic axis and mitochondrial dysfunction lead to the occurrence and development of NAFLD. Curcumin, a natural polyphenol, is a potential drug for the treatment of NAFLD, and has been widely studied in experimental researches. This study reviewed pathogenesis of NAFLD and the therapeutic effect of curcumin on NAFLD.