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章松林, 严玲玲, 吴家园. 鼻内镜手术治疗鼻咽癌残留患者的疗效观察[J]. 实用临床医药杂志, 2019, 23(23): 64-66. DOI: 10.7619/jcmp.201923019
引用本文: 章松林, 严玲玲, 吴家园. 鼻内镜手术治疗鼻咽癌残留患者的疗效观察[J]. 实用临床医药杂志, 2019, 23(23): 64-66. DOI: 10.7619/jcmp.201923019
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ZHANG Songlin, YAN Lingling, WU Jiayuan. Efficacy observation of endoscopic sinus surgery in treatment of patients with residual nasopharyngeal carcinoma[J]. Journal of Clinical Medicine in Practice, 2019, 23(23): 64-66. DOI: 10.7619/jcmp.201923019
Citation: ZHANG Songlin, YAN Lingling, WU Jiayuan. Efficacy observation of endoscopic sinus surgery in treatment of patients with residual nasopharyngeal carcinoma[J]. Journal of Clinical Medicine in Practice, 2019, 23(23): 64-66. DOI: 10.7619/jcmp.201923019
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鼻内镜手术治疗鼻咽癌残留患者的疗效观察

Efficacy observation of endoscopic sinus surgery in treatment of patients with residual nasopharyngeal carcinoma

    摘要
  • 摘要:
      目的  探讨鼻内镜手术治疗鼻咽癌残留患者的疗效。
      方法  将96例鼻咽癌残留患者随机分为对照组与实验组。对照组采用传统开放切除术, 实验组采用鼻内镜切除术。比较2组手术相关指标、并发症发生情况、手术前后免疫功能指标及炎症因子指标变化。
      结果  实验组手术时间、术中出血量、住院时间显著优于对照组(P < 0.05); 与术前相比，实验组术后CD4+、CD4+/CD8+上升, CD8+水平下降，且均显著优于对照组(P < 0.05); 实验组术后C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)水平显著低于对照组(P < 0.05); 实验组术后并发症发生率6.25%, 显著低于对照组22.92%(P < 0.05)。
      结论  鼻内镜手术治疗鼻咽癌残留患者疗效确切，可减轻机体组织创伤，降低术后并发症发生率。

     

    Abstract:
      Objective  To explore the efficacy of endoscopic sinus surgery in treatment of patients with residual nasopharyngeal carcinoma.
      Methods  Totally 96 patients with residual nasopharyngeal carcinoma were randomly divided into control group and experimental group. Control group was treated with conventional open resection of nasopharyngeal carcinoman, and experimental group was treated with endoscopic sinus surgery. The surgical indexes, complications, the changes of immune function indexes and inflammatory factors before and after surgery were compared between two groups.
      Results  The operation time, intra-operative bleeding volume and hospital stay in experimental group were significantly better than those in control group (P < 0.05). Compared with indexes before surgery, the CD4+ and CD4+/CD8+ in experimental group increased significantly after surgery, the CD8+ significantly decreased, and these indexes in experimental group after operation were significantly better than those in control group (P < 0.05). After surgery, the levels of C reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) in experimental group were significantly lower than those in control group (P < 0.05). The incidence rate of postoperative complications in experimental group was 6.25%, which was lower than 22.92% in control group (P < 0.05).
      Conclusion  Endoscopic sinus surgery is effective in treatment of patients with residual nasopharyngeal carcinoma, which can reduce tissue traumaand postoperative complications.

     

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