Objective  To investigate the prognosis of neonatal asphyxia patients complicated with hypoxic ischemic encephalopathy (HIE) treated by monosialotetrahexosylganglioside (GM1) combined with mild hypothermia therapy.

  Methods  A total of 80 neonates with neonatal asphyxia complicated with HIE admitted to our hospital were divided into control group (n=40, mild hypothermia) and observation group (n=40, CM1 combined with mild hypothermia) according to the random number table method. The therapeutic effects of the two groups were compared.

  Results  After treatment, the Neonatal Behavioral Neurological Assessment (NBNA) scores in the observation group was higher than that in the control group, and the improvement of oxidative stress response was better than that in the control group (P < 0.05). The recovery time of sucking ability, consciousness, original reflex and muscle tension in the observation group were shorter than that in the control group, and the total incidence of sequelae was lower than that in the control group (P < 0.05).

  Conclusion  Monosialotetrahexosylganglioside combined with mild hypothermia therapy in the treatment of neonatal asphyxia complicated with HIE can improve the neurological function of infants.