Objective  To explore the clinical efficiency of laparoscopic ovarian perforation combined with clomiphene citrate (CC) and human chorionic gonadotropin (HCG) in treating infertility induced by polycystic ovary syndrome (PCOS).

  Methods  Totally 68 patients with infertility induced by PCOS were randomly divided into two groups, with 34 cases in each group. The control group was treated with laparoscopic ovarian perforation and HCG, while the observation group was treated with laparoscopic ovarian perforation combined with CC and HCG. Therapeutic effect and pregnancy condition were compared between the two groups.

  Results  After treatment, the levels of luteinizing hormone, estradiol and testosterone in the observation group were significantly better than those in the control group (P < 0.05). In the observation group, the ovulation rate and one-year pregnancy rate were 91.18% and 58.82% respectively, which were significantly higher than 58.82% and 32.35% in the control group (P < 0.05). There were no adverse reactions in the control group, and the incidence rate of adverse reactions in the observation group was 5.58%. There was no significant difference between the two groups (P>0.05).

  Conclusion  Laparoscopic ovarian perforation combined with CC and HCG is effective in the treatment of infertility induced by PCOS, which can improve sex hormone level and increase ovulation rate and pregnancy rate.