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龚芸. 厄贝沙坦联合小剂量利尿剂对老年单纯收缩期高血压患者血清炎症因子及血管内皮功能的影响[J]. 实用临床医药杂志, 2019, (4): 54-56. DOI: 10.7619/jcmp.201904016
引用本文: 龚芸. 厄贝沙坦联合小剂量利尿剂对老年单纯收缩期高血压患者血清炎症因子及血管内皮功能的影响[J]. 实用临床医药杂志, 2019, (4): 54-56. DOI: 10.7619/jcmp.201904016
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GONG Yun. Effect of irbesartan tablets combined with a small dose of diuretics on serum inflammatory factors and vascular endothelial function in elderly patients with isolated systolic hypertension[J]. Journal of Clinical Medicine in Practice, 2019, (4): 54-56. DOI: 10.7619/jcmp.201904016
Citation: GONG Yun. Effect of irbesartan tablets combined with a small dose of diuretics on serum inflammatory factors and vascular endothelial function in elderly patients with isolated systolic hypertension[J]. Journal of Clinical Medicine in Practice, 2019, (4): 54-56. DOI: 10.7619/jcmp.201904016
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厄贝沙坦联合小剂量利尿剂对老年单纯收缩期高血压患者血清炎症因子及血管内皮功能的影响

Effect of irbesartan tablets combined with a small dose of diuretics on serum inflammatory factors and vascular endothelial function in elderly patients with isolated systolic hypertension

    摘要
  • 摘要: 目的 研究厄贝沙坦联合小剂量利尿剂对老年单纯收缩期高血压患者对其血清炎症因子及血管内皮功能影响.方法 将本院收治的老年单纯收缩期高血压患者204例,按照随机数表法平均分为2组.其中对照组102例,给予小剂量氢氯噻嗪片;观察组在对照组基础上联合厄贝沙坦片.对比治疗前和治疗4周后2组患者的收缩压和舒张压、血清炎症因子、血管内皮功能指标、不良反应及临床疗效.结果 治疗后,2组患者内皮素-1(ET-1)降低而一氧化氮(NO)增加(P＜0.05),且观察组NO高于对照组而ET-1低于对照组(P＜0.05).治疗后,2组患者超敏C反应蛋白(hs-CRP)及可溶性细胞间黏附分子-1(sICAM-1)均降低(P＜0.05),且观察组低于对照组(P＜0.05).2组患者不良反应发生率相比,差异无统计学意义(P＞0.05).但观察组治疗总有效率为94.1％,高于对照组的74.5％ (P ＜0.05).结论 厄贝沙坦联合小剂量利尿剂治疗老年单纯收缩期高血压,可有效改善其舒张压和收缩压,改善血清炎症因子及血管内皮功能,具有疗效好、不良反应低等优点.

     

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