Abstract: Objective To retrospectively analyze the clinical significance of serum uric acid (UA)and hypersensitivity C-reactive protein (hs-CRP)in monitoring the conditions of patients with stable angina pectoris (SAP).Methods Serum UA and hs-CRP levels in SAP patients were detected,and were divided into stable group (98 cases)and progressive group (48 cases)after 1-year follow up and observation.Serum UA and hs-CRP levels were detected in both groups.And another 50 healthy people were selected as control group to compare the serum UA and hs-CRP lev-els.Results In primary investigation,serum UA and hs-CRP levels in stable and progressive groups were evidently higher than in control group (P <0.01),and were obviously higher in progressive group than in stable group (P <0.01).After re-examination,they had slight increase in stable group than in primary investigation,but the difference was not significant (P >0.05).However, they were markedly higher in progressive after re-examination than in primary investigation and sta-ble group (P <0.01).Conclusion Serum UA and hs-CRP levels in patients with SAP are closely associated with the development and prognosis of SAP,whose detections are helpful in investigating disease severity and conduct early treatment.