Abstract: Objective To explore value of MSCT in diagnosis of controllable rabbit model of acute pancreatitis.Methods 16 rabbits were divided into normal group (n =3)and experimental group (n =13).The experimental group was treated with ligation and injection of pancreatic duct to make the controllable model of acute pancreatitis.The assay of serum amylase and 64-slice CT scan were performed after 4 hours,8 hours of modeling in both groups.The CT scan included plain scan of pancreas,enhancement scanning of pancreatic phase (38 ~43 s)and hepatic phase (52 ~58 s).Im-ages were retrospectively reconstructed under different reformations of multiplanar reconstruction (MPR)and curved planar reconstruction (CPR).Results The numerical value of amylase was (133.12 ±27.93)U /L in normal group,and (263.50 ±41.73)U /L after 4 hours of modeling and (338.87 ±75.23)U /L after 8 hours of modeling in experimental group.There was no significant difference of CT scan between experimental group after 4 hours of modeling and the normal group.In the rabbits of 8 hours after modeling,the CT scan showed pancreatic enlargement (11 /13,84.6%), lower density (5 /13,38.5%)in the plain scan and non-uniform enhancing(7 /13,53.8%)at pan-creatic phase.In experimental group,CT imaging changes of pancreatitis appeared about 4 hours later than amylase changes.Conclusion Implementation of MSCT plain and enhanced scanning for con-trollable rabbit model of acute pancreatitis plays an important value in identifying the pathogenesis and early development process of acute pancreatitis.