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杜雨柔, 赵亚东, 刘斌, 雷星, 李建, 吴耀禄, 除妮妮. 口服来曲唑对绝经后乳腺癌患者血清血管内皮生长因子的影响[J]. 实用临床医药杂志, 2011, (19): 97-98,102. DOI: 10.3969/j.issn.1672-2353.2011.19.034
引用本文: 杜雨柔, 赵亚东, 刘斌, 雷星, 李建, 吴耀禄, 除妮妮. 口服来曲唑对绝经后乳腺癌患者血清血管内皮生长因子的影响[J]. 实用临床医药杂志, 2011, (19): 97-98,102. DOI: 10.3969/j.issn.1672-2353.2011.19.034
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DU Yu-rou, ZHAO Ya-dong, LIU Bin, LEI Xing, LI Jian, WU Yao-lu, XU Ni-ni. Effect of oral Letrozole treatment on serum vascular endothelial growth factor in postmenopausal breast cancer[J]. Journal of Clinical Medicine in Practice, 2011, (19): 97-98,102. DOI: 10.3969/j.issn.1672-2353.2011.19.034
Citation: DU Yu-rou, ZHAO Ya-dong, LIU Bin, LEI Xing, LI Jian, WU Yao-lu, XU Ni-ni. Effect of oral Letrozole treatment on serum vascular endothelial growth factor in postmenopausal breast cancer[J]. Journal of Clinical Medicine in Practice, 2011, (19): 97-98,102. DOI: 10.3969/j.issn.1672-2353.2011.19.034
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口服来曲唑对绝经后乳腺癌患者血清血管内皮生长因子的影响

Effect of oral Letrozole treatment on serum vascular endothelial growth factor in postmenopausal breast cancer

    摘要
  • 摘要: 目的 通过测定绝经后女性乳腺癌患者口服来曲唑治疗前、后血清血管上皮生长因子(VEGF)的浓度变化,观察血清VEGF与绝经后乳腺癌患者来曲唑疗效之间的相关性.方法 采用酶联免疫吸附法(ELISA)分别检测49例绝经后乳腺癌患者来曲唑治疗前、治疗1年后血清VFGGF水平,并以33名正常健康志愿者血清VEGF水平作为对照.结果 49例绝经后乳腺癌患者服药前血清VEGF水平明显高于对照组(P＜0.01),服用来曲唑治疗1年后血清VEGF显著下降(P＜0.01),且ER(+)患者血清VEGF下降程度显著高于ER(-)患者(P＜0.01).结论 口服来曲唑治疗绝经后女性乳腺癌患者血清VEGF表达下降,有助于预防乳腺癌复发和转移.

     

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