杨娟, 钱玮和, 韩雪花, 柏进, 成玉花, 许将, 单春明. 白三烯受体拮抗剂对毛细支气管炎外周血CD4+CD25+ Treg的影响及疗效观察[J]. 实用临床医药杂志, 2010, (21): 19-21. DOI: 10.3969/j.issn.1672-2353.2010.21.006
引用本文: 杨娟, 钱玮和, 韩雪花, 柏进, 成玉花, 许将, 单春明. 白三烯受体拮抗剂对毛细支气管炎外周血CD4+CD25+ Treg的影响及疗效观察[J]. 实用临床医药杂志, 2010, (21): 19-21. DOI: 10.3969/j.issn.1672-2353.2010.21.006
YANG Juan, QIAN Wei-he, HAN Xue-hua, BAI Jin, CHENG Yu-hua, XU Jiang, SHAN Chun-ming. Effects of Leukotriene receptor antagonists on CD4+CD25+T cell and curative effect observation in children with bronchiolitis[J]. Journal of Clinical Medicine in Practice, 2010, (21): 19-21. DOI: 10.3969/j.issn.1672-2353.2010.21.006
Citation: YANG Juan, QIAN Wei-he, HAN Xue-hua, BAI Jin, CHENG Yu-hua, XU Jiang, SHAN Chun-ming. Effects of Leukotriene receptor antagonists on CD4+CD25+T cell and curative effect observation in children with bronchiolitis[J]. Journal of Clinical Medicine in Practice, 2010, (21): 19-21. DOI: 10.3969/j.issn.1672-2353.2010.21.006

白三烯受体拮抗剂对毛细支气管炎外周血CD4+CD25+ Treg的影响及疗效观察

Effects of Leukotriene receptor antagonists on CD4+CD25+T cell and curative effect observation in children with bronchiolitis

  • 摘要: 目的 探讨白三烯受体拮抗剂(孟鲁司特)对毛细支气管炎患儿外周血CD4+CD25+调节性T细胞(Treg)的影响并观察其疗效.方法 将48例毛细支气管炎患儿按入院顺序分成孟鲁司特干预组和常规治疗组,常规治疗组采取综合治疗,孟鲁司特干预组在综合治疗的基础上加用孟鲁司特4 mg,每晚1次口服.检测2组患者治疗前后外周血中CD4+CD25+ Treg的水平,并观察2组患者咳嗽、喘憋、肺部体征的持续时间.结果 治疗前2组患儿外周血CD4+CD25+Treg占CD4+ T细胞的百分比均明显低于健康对照组,差异有统计学意义(P<0.01);治疗后孟鲁司特干预组外周血中CD4+CD25+ Treg水平较常规治疗组显著上升(P<0.05),同时咳嗽、喘憋、肺部体征持续时间与常规治疗组比较有统计学意义(P<0.01).结论 孟鲁斯特纳可缩短病程,提高毛细支气管炎患儿外周血CD4+CD25+ Treg的水平,在毛细支气管炎的治疗中起重要作用.

     

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