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张瑜, 卜平. 肠易激综合征患者负性情感与肠CCK、c-fos相关性研究[J]. 实用临床医药杂志, 2010, (19): 29-31,33. DOI: 10.3969/j.issn.1672-2353.2010.19.008
引用本文: 张瑜, 卜平. 肠易激综合征患者负性情感与肠CCK、c-fos相关性研究[J]. 实用临床医药杂志, 2010, (19): 29-31,33. DOI: 10.3969/j.issn.1672-2353.2010.19.008
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ZHANG Yu, BO Ping. Correlation between negative and intestinal CCK and c-fos in patients with irritable bowel syndrom[J]. Journal of Clinical Medicine in Practice, 2010, (19): 29-31,33. DOI: 10.3969/j.issn.1672-2353.2010.19.008
Citation: ZHANG Yu, BO Ping. Correlation between negative and intestinal CCK and c-fos in patients with irritable bowel syndrom[J]. Journal of Clinical Medicine in Practice, 2010, (19): 29-31,33. DOI: 10.3969/j.issn.1672-2353.2010.19.008
shu

肠易激综合征患者负性情感与肠CCK、c-fos相关性研究

Correlation between negative and intestinal CCK and c-fos in patients with irritable bowel syndrom

    摘要
  • 摘要: 目的 探讨胆囊收缩素(CCK)、细胞癌基因fos(c-fos)的表达与肠易激综合征(IBS) 患者负性情感的关联.方法 采用SCL-90量表对IBS患者和正常对照组进行测试,评定心理状况;采用免疫组化法分析IBS患者及正常对照组乙状结肠和回盲部黏膜CCK、c-fos的含量.结果 IBS患者存在明显的焦虑、抑郁、敌对负性情感;IBS腹泻型患者结肠黏膜中c-fos的表达显著高于正常组及IBS便秘型组(P<0.01); IBS患者焦虑、抑郁与乙状结肠和回盲部黏膜CCK、c-fos的表达相关.结论 肠易激综合征患者焦虑、抑郁与结肠黏膜CCK、c-fos的表达相关.

     

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