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罗惠媛, 周国栋, 陶金, 陈洁. 3H-thymidine渗入法测定Urocortin对大鼠血管平滑肌细胞增殖的影响[J]. 实用临床医药杂志, 2006, (1): 37-38. DOI: 10.3969/j.issn.1672-2353.2006.01.012
引用本文: 罗惠媛, 周国栋, 陶金, 陈洁. 3H-thymidine渗入法测定Urocortin对大鼠血管平滑肌细胞增殖的影响[J]. 实用临床医药杂志, 2006, (1): 37-38. DOI: 10.3969/j.issn.1672-2353.2006.01.012
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LUO Hui-yuan, ZHOU Guo-dong, TAO Jin, CHRN Jie. The effect of urocortin on proliferation of rat vascular smooth muscle cells measured by 3 H-thymidine[J]. Journal of Clinical Medicine in Practice, 2006, (1): 37-38. DOI: 10.3969/j.issn.1672-2353.2006.01.012
Citation: LUO Hui-yuan, ZHOU Guo-dong, TAO Jin, CHRN Jie. The effect of urocortin on proliferation of rat vascular smooth muscle cells measured by 3 H-thymidine[J]. Journal of Clinical Medicine in Practice, 2006, (1): 37-38. DOI: 10.3969/j.issn.1672-2353.2006.01.012
shu

3H-thymidine渗入法测定Urocortin对大鼠血管平滑肌细胞增殖的影响

The effect of urocortin on proliferation of rat vascular smooth muscle cells measured by 3 H-thymidine

    摘要
  • 摘要: 目的探讨Urocortin(UCN)对大鼠血管平滑肌细胞增殖的影响.方法分离、培养大鼠血管平滑肌细胞,分别加入不同浓度的UCN以及UCN+Astressin, UCN+Glybenclamide培养,采用3H-thymidine掺入法,观察不同浓度UCN对血管平滑肌细胞增殖的影响,及其相关作用机制.结果随着Urocortin浓度的增高, VSMC对3H-thymidine摄取率呈下降趋势,而该作用不受Astressin或Glybenclamide 的影响.结论 Urocortin具有抑制大鼠血管平滑肌细胞增殖的作用,其作用不是通过CRF受体或KATP通道.

     

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