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张莉莉, 朱月清, 沈宗丽, 胡赛男, 吴剑秋, 周振英, 孙蔚莉, 冯继锋. 流式细胞术检测乳腺癌患者血细胞中C-erbB-2表达水平及意义[J]. 实用临床医药杂志, 2005, (11): 12-15. DOI: 10.3969/j.issn.1672-2353.2005.11.004
引用本文: 张莉莉, 朱月清, 沈宗丽, 胡赛男, 吴剑秋, 周振英, 孙蔚莉, 冯继锋. 流式细胞术检测乳腺癌患者血细胞中C-erbB-2表达水平及意义[J]. 实用临床医药杂志, 2005, (11): 12-15. DOI: 10.3969/j.issn.1672-2353.2005.11.004
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ZHANG Li-li, ZHU Yue-qing, SHEN Zong-li, HU Sai-nan, WU Jian-qiu, ZHOU Zhen-ying, SUN Wei-li, FENG Ji-feng. THE EXPRESSION AND SIGNIFICANCE OF C-erbB-2 IN PERIPHERAL BLOOD MONONUCLER CELL OF PATIENT WITH BREAST CANCER BY FLOW CYTOMETRY[J]. Journal of Clinical Medicine in Practice, 2005, (11): 12-15. DOI: 10.3969/j.issn.1672-2353.2005.11.004
Citation: ZHANG Li-li, ZHU Yue-qing, SHEN Zong-li, HU Sai-nan, WU Jian-qiu, ZHOU Zhen-ying, SUN Wei-li, FENG Ji-feng. THE EXPRESSION AND SIGNIFICANCE OF C-erbB-2 IN PERIPHERAL BLOOD MONONUCLER CELL OF PATIENT WITH BREAST CANCER BY FLOW CYTOMETRY[J]. Journal of Clinical Medicine in Practice, 2005, (11): 12-15. DOI: 10.3969/j.issn.1672-2353.2005.11.004
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流式细胞术检测乳腺癌患者血细胞中C-erbB-2表达水平及意义

THE EXPRESSION AND SIGNIFICANCE OF C-erbB-2 IN PERIPHERAL BLOOD MONONUCLER CELL OF PATIENT WITH BREAST CANCER BY FLOW CYTOMETRY

    摘要
  • 摘要: 目的探讨乳腺癌患者外周血中单个核细胞(PBMC)中C-erbB-2的表达水平及其与肿瘤组织中C-erbB-2、激素受体(ER、PR)表达状态及与病期的相关性.方法采用流式细胞术检测77例乳腺癌患者PBMC中C-erbB-2表达水平并与肿瘤组织中C-erbB-2、激素受体(ER、PR)表达状态及与病期进行比较.结果 77例乳腺癌患者PBMC中C-erbB-2检测水平为(24.16±20.81)%.瘤组织中C-erbB-2阳性者的PBMC中的C-erbB-2值(30.69±21.70)%, 高于瘤组织C-erbB-2阴性值(17.47±17.48)%, 2者有显著性差异(P＜0.01).肿瘤组织中激素受体阴性与阳性者、临床分期Ⅲ～Ⅵ患者与Ⅰ～Ⅱ期患者PBMC的C-erbB-2均值无明显差别(P>0.05).结论乳腺癌患者PBMC中C-erbB-2的表达水平与瘤组织中C-erbB-2的表达状态密切相关,与病期、瘤组织的激素受体表达状态无关.为进一步用FCM研究外周血中C-erbB-2对预后判断的影响及用于指导治疗提供依据.

     

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