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黄永生, 王淑玉, 马志松, 孔祥, 成红霞. CA125及其半衰期监测进展期卵巢癌疗效和预后的意义[J]. 实用临床医药杂志, 2002, (4): 340-342. DOI: 10.3969/j.issn.1672-2353.2002.04.023
引用本文: 黄永生, 王淑玉, 马志松, 孔祥, 成红霞. CA125及其半衰期监测进展期卵巢癌疗效和预后的意义[J]. 实用临床医药杂志, 2002, (4): 340-342. DOI: 10.3969/j.issn.1672-2353.2002.04.023
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SIGNIFICANCE OF SERUM CA125 AND ITS HALF-LIFE IN MONITORING THE RESPONSE TO TREATMENT AND PROGNOSIS OF ADVANCED OVARIAN CANCER[J]. Journal of Clinical Medicine in Practice, 2002, (4): 340-342. DOI: 10.3969/j.issn.1672-2353.2002.04.023
Citation: SIGNIFICANCE OF SERUM CA125 AND ITS HALF-LIFE IN MONITORING THE RESPONSE TO TREATMENT AND PROGNOSIS OF ADVANCED OVARIAN CANCER[J]. Journal of Clinical Medicine in Practice, 2002, (4): 340-342. DOI: 10.3969/j.issn.1672-2353.2002.04.023
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CA125及其半衰期监测进展期卵巢癌疗效和预后的意义

SIGNIFICANCE OF SERUM CA125 AND ITS HALF-LIFE IN MONITORING THE RESPONSE TO TREATMENT AND PROGNOSIS OF ADVANCED OVARIAN CANCER

    摘要
  • 摘要: 目的:研究CA125及其半衰期监测进展期卵巢癌疗效及预后的应用价值.方法:采用化学发光法测定45例Ⅲ、Ⅳ期原发卵巢癌患者血浆CA125水平并计算CA125半衰期.结果:45例患者治疗前血浆CA125水平均高于正常;采用单因素生存率时序检验(Log rank test)分析表明,第3次化疗后CA125水平、CA125半衰期及手术后残留灶大小、FIGO分期对预后有影响(P值分别为0.0010、0.0000、0.0002、0.0385);运用Cox风险回归模型进行多因素分析表明:CA125半衰期对进展期卵巢癌患者有独立的预后价值(χ2=6.2734,P=0.0123).结论:化疗早期CA125水平及其半衰期对进展期卵巢癌患者的预后评定有价值,检测该指标可及时发现耐药或复发,可及时给予相应的治疗措施.

     

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