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丁建东, 吴翔, 顾勇. 扩张型心肌病抗人心肌线粒体抗体的临床研究[J]. 实用临床医药杂志, 2001, (2): 95-98. DOI: 10.3969/j.issn.1672-2353.2001.02.001
引用本文: 丁建东, 吴翔, 顾勇. 扩张型心肌病抗人心肌线粒体抗体的临床研究[J]. 实用临床医药杂志, 2001, (2): 95-98. DOI: 10.3969/j.issn.1672-2353.2001.02.001
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THE CLINICAL STUDY OF AUTOANTIBODY AGAINST MITOCHONDRIA OF HUMAN MYOCARDIUM IN DILATED CARDIOMYOPATHY[J]. Journal of Clinical Medicine in Practice, 2001, (2): 95-98. DOI: 10.3969/j.issn.1672-2353.2001.02.001
Citation: THE CLINICAL STUDY OF AUTOANTIBODY AGAINST MITOCHONDRIA OF HUMAN MYOCARDIUM IN DILATED CARDIOMYOPATHY[J]. Journal of Clinical Medicine in Practice, 2001, (2): 95-98. DOI: 10.3969/j.issn.1672-2353.2001.02.001
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扩张型心肌病抗人心肌线粒体抗体的临床研究

THE CLINICAL STUDY OF AUTOANTIBODY AGAINST MITOCHONDRIA OF HUMAN MYOCARDIUM IN DILATED CARDIOMYOPATHY

    摘要
  • 摘要: 目的:检测扩张型心肌病(DCM)患者血清中是否有抗人心肌线粒体抗体存在及其意义.方法:以人心肌线粒体作抗原,应用免疫点印迹(Immuno-dot b1ot)对24例DCM、20例健康献血者(HBD)进行抗人心肌线粒体抗体检测,用Westemblot方法检测其抗原分子量.结果:10例(41.7%)DCM患者抗人心肌线粒体抗体阳性,而HBD组0%;早期患者阳性率(70%)明显高于晚期患者(21.4%)(P＜0.05);DCM抗体阳性与阴性患者之间心功能指标(左室射血分数、左室舒张末期内径、心胸比例)无明显差异(P＞0.05);人心肌线粒体特异性抗原的分子量为30KD.结论:①在DCM患者血清中存在抗人心肌线粒体抗体,支持DCM与自身免疫有关,对该抗体的检测可作为DCM的辅助诊断手段之一;②该抗体是DCM患者的早期指标,随着病程的进展,逐渐消失;③DCM抗人心肌线粒体抗体的检出率与心功能无明显关系;④该抗体的特异性抗原可能为人心肌线粒体腺苷酸转位酶.

     

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