Influence of hyperuricemia on deep vein thrombosis of lower extremities after artificial joint replacement

Objective To investigate the impact of hyperuricemia on risk of deep vein thrombosis after joint replacement surgery.

Methods A total of 953 patients undergoing joint replacement surgery were enrolled in this study. Among them, 662 patients did not develop thrombosis postoperatively (postoperative non-thrombosis group), while 291 patients developed thrombosis (postoperative thrombosis group). Data including gender, age, surgical procedure, body mass index, hypertension, coronary heart disease, diabetes, preoperative D-dimer positivity (≥0.5 mg/L), prothrombin time, prothrombin activity, international normalized ratio, activated partial thromboplastin time, fibrinogen, thrombin time, white blood cell count, red blood cell count, hemoglobin, hematocrit and platelet count were analyzed. Logistic regression analysis was used to identify independent risk factors for postoperative deep vein thrombosis.

Results Univariate analysis showed that age, gender, surgical procedure (total knee arthroplasty), hypertension, diabetes, hyperuricemia, preoperative red blood cell count, preoperative hematocrit and preoperative D-dimer positivity were influencing factors for deep vein thrombosis after joint replacement surgery (P < 0.05). Logistic regression analysis revealedthat age (>60 years), surgical procedure (total knee arthroplasty) and hyperuricemia were independent risk factors for postoperative deep vein thrombosis (P < 0.05).

Conclusion Hyperuricemia is an independent risk factor for deep vein thrombosis after joint replacement surgery.