Advances in role of gut-liver axis in non-alcoholic fatty liver disease

The gut-liver axis is critical pathway of interaction between the intestine and the liver, involving gut microbiota, intestinal permeability and immune responses.Dysbiosis of the gut microbiota and increased intestinal permeability lead to the translocation of bacteria and their metabolites into the systemic circulation, thereby triggering hepatic inflammation and promoting the progression of non-alcoholic fatty liver disease (NAFLD).Research on the gut-liver axis contributes to the development of novel therapeutic approaches, including fecal microbiota transplantation, antibiotic therapy and nutritional intervention, providing new insights for the treatment of NAFLD.This article reviewed the composition and regulatory mechanism of entero-hepatic axis, its relationship with NAFLD, and the role of drug therapy and lifestyle intervention.