Objective To observe the incidence of vascular calcification in patients with chronic renal failure (CRF) undergoing maintenance hemodialysis and analyze the related influencing factors.
Methods A total of 110 CRF patients undergoing maintenance hemodialysis at Xingtai Central Hospital in Hebei Province were selected. Vascular calcification was determined through hip, abdominal, and bilateral hand X-ray examinations, and patients were divided into calcification group (n=59, with mild, moderate, and severe calcification) and non-calcification group (n=51, without calcification) based on the calcification results. General information and laboratory indicators white blood cell (WBC) count, hemoglobin (Hb), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), albumin (LB), serum potassium (K), serum calcium (Ca), serum phosphorus (P), serum creatinine (SCr), urea nitrogen (BUN), uric acid (UA), intact parathyroid hormone (iPTH), high-sensitivity C-reactive protein (hs-CRP), interleukin-13 (IL-13), fibroblast growth factor 23 (FGF23), sclerostin (SOST)were compared between the two groups, and Logistic regression analysis was performed to screen influencing factors of vascular calcification.
Results There were no statistically significant differences in gender, body mass index, smoking history, and primary renal diseases between the calcification and non-calcification groups(P>0.05). The mean age and dialysis duration were higher in the calcification group compared to the non-calcification group (P < 0.05). There were no statistically significant differences in WBC, Hb, TC, TG, HDL-C, LDL-C, K, Ca, and BUN levels between the two groups (P>0.05). Compared with the non-calcification group, the calcification group had lower ALB and UA levels and higher P, SCr, iPTH, hs-CRP, IL-13, FGF23, and SOST levels(P < 0.05). Multivariate Logistic regression analysis showed that age, dialysis duration, and levels of P, iPTH, IL-13, FGF23, and SOST were influencing factors for vascular calcification in patients (P < 0.05). The receiver operating characteristic curve indicated that IL-13, FGF23, and SOST had certain diagnostic value for vascular calcification in patients area under the curve (AUC) >0.7, and the diagnostic efficacy of combined IL-13, FGF23, and SOST was higher than that of each indicator alone (AUC=0.911, P < 0.05).
Conclusion Vascular calcification is common in CRF patients undergoing maintenance hemodialysis, and age, dialysis duration, P, IL-13, FGF23, and SOST are influencing factors for vascular calcification.
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