Effect of topical application of recombinant human acidic fibroblast growth factor on healing of burn and scald wounds

Objective To analyze the effect of topical recombinant human acidic fibroblast growth factor (rh-aFGF) on wound healing in burn and scald patients.

Methods A total of 240 burn patients were selected as the study subjects and divided into observation group and control group, with 120 cases in each group. The control group was treated with compound polymyxin B ointment, while the observation group received rh-aFGF combined with compound polymyxin B ointment. The wound healing time, wound healing rate, positive detection rate of wound pathogens and wound inflammatory response were compared between the two groups after treatment.

Results After 28 days of medication, the wound healing time of patients in the observation group was significantly shorter, and the wound healing rate was significantly higher than that in the control group (P < 0.05). The detection rate of pathogens in the burn wounds of the observation group was significantly lower than that of the control group at 7, 14, 21, and 28 days after treatment (P < 0.05). There was a statistically significant difference in wound inflammatory response between the two groups (P < 0.05).

Conclusion The rh-aFGF is effective in treatment of burn and scald wound, and it is conductive to promoting wound healing, shortening healing time, and reducing wound inflammatory responses.