Correlations of D-dimer and the Global Registry of Acute Coronary Events score with long-term heart failure in patients with acute myocardial infarction

SHEN Jiarui; ZHANG Jiajia; CHEN Senyang; QIAN Yan; CHEN Zhiqian; YE Xinying; ZHAO Pei

doi:10.7619/jcmp.20242129

Journal of Clinical Medicine in Practice > 2024 > 28(22): 99-104. > DOI: 10.7619/jcmp.20242129

SHEN Jiarui, ZHANG Jiajia, CHEN Senyang, QIAN Yan, CHEN Zhiqian, YE Xinying, ZHAO Pei. Correlations of D-dimer and the Global Registry of Acute Coronary Events score with long-term heart failure in patients with acute myocardial infarction[J]. Journal of Clinical Medicine in Practice, 2024, 28(22): 99-104. DOI: 10.7619/jcmp.20242129

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Correlations of D-dimer and the Global Registry of Acute Coronary Events score with long-term heart failure in patients with acute myocardial infarction

1.
Department of Cardiovascular, the Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, 225000
2.
Department of Cardiovascular, the First People's Hospital of Pingdingshan City in Henan Province, Pingdingshan, Henan, 467000

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Received Date: May 20, 2024
Revised Date: August 27, 2024

Graphical Abstract

Abstract

Abstract

Objective
To analyze the correlations of D-dimer and the Global Registry of Acute Coronary Events (GRACE) score with long-term heart failure (HF) in patients with acute myocardial infarction (AMI).
Methods
A total of 398 patients with AMI were selected as research objects and divided into normal D-dimer group (n=309) and elevated D-dimer group (n=89) based on the D-dimer level. Cox proportional hazard model was used to analyze the risk factors for long-term HF in both groups. Time-dependent receiver operating characteristic (ROC) curve was used to analyze the values of D-dimer, GRACE score and their combination in predicting long-term HF. According to the GRACE score and D-dimer level, 398 patients were divided into low-value group (181 patients with normal D-dimerand low GRACE score), high-value group (70 patients with elevated D-dimer and high GRACE score), and middle-value group (147 patients did not meet the conditions of the low-value and high-value groups). Kaplan-Meier method was used to analyze the occurrence of long-term HF in the three groups. Point-biserial analysis was used to analyze the correlation between elevated D-dimer and the occurrence of long-term HF.
Results
The number of patients with long-term HF in the elevated D-dimer group was 2.3 times of the normal group. D-dimer and GRACE score were independent risk factors for long-term HF in patients with AMI (P < 0.05). Both D-dimer and GRACE score had certain predictive values for the occurrence of HF at 5 years after AMI, but the predictive efficiency of GRACE score was better. The incidence of long-term HF in the high-value group was significantly higher than that in the low-value group and the middle-value group (P < 0.01). D-dimer was significantly positively correlated with the occurrence of long-term HF after AMI (P < 0.001).
Conclusion
Both D-dimer and GRACE score are independent risk factors for long-term HF in patients with AMI, and the two indexes have certain predictive value for the occurrence of long-term HF. Patients with both elevated indicators are high-risk groups for long-term HF.
- D-dimer,
- the Global Registry of Acute Coronary Events score,
- acute myocardial infarction,
- heart failure,
- correlation

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References (19)

References

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Correlations of D-dimer and the Global Registry of Acute Coronary Events score with long-term heart failure in patients with acute myocardial infarction

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